Transmigration

Transmigration of leukocytes from the lumen of the blood vessels to the underlying tissue is a key process in immunosurveillance and in the response to inflammation and injury in the normal function of the immune system. However, in inflammatory diseases and cancer, transmigration of cells to underlying tissues is a gateway to metastasis and morbidity. The significance of transmigration of unwanted cells to underlying tissues and through the blood brain barrier from the vasculature in disease states makes it an important target for drug development. As such, transmigration is a prime target for inflammation and oncology drug discovery.




The BioFlux System provides numerous advantages to the study of transmigration:

• Supports a wide variety of cellular monolayer types and adhesion coatings
• Provides straight forward method for quantitative transmigration assay
• Enables high resolution imaging of endothelial and circulating cells
• Permits continual time-lapse microscopy to capture significant events

 More information can be found in our Cellular Biology Application Notes.