BioFlux

Products for Functional Cell Assays

Live cell assays with controlled shear flow

BioFlux provides a fully integrated solution for running biologically relevant cellular assays under shear flow. The system utilizes Fluxion's Well Plate Microfluidics™ (WPM) to provide high content results from a convenient well-plate format. Precise control over shear flow enables a wide variety of cellular and microbiology applications which call for vascular emulation, mechanical stress, compound/buffer exchange and high content analysis.


     


BioFlux supports a wide range of live cell applications

BioFlux enables a wide variety of cell-based assays in the fields of immunology, vascular biology, microbiology, cancer research, stem cells, and more. Many of these applications benefit from the ability to create a physiologically-relevant shear flow profile, such as platelet adhesion, cell adhesion, rolling velocity, transmigration, and stem cell differentiation. Other applications can benefit from the ability to introduce compounds and gradients in a time-resolved and well-controlled manner, such as wound healing, chemotaxis, pharmacology and neurite-outgrowth assays.



Microfluidic approach improves throughput and minimizes
reagent use

The BioFlux system utilizes a unique microfluidic design to enable automated cellular analyses in the presence of controlled shear flow. Micron-scale flow channel devices are integrated into SBS-standard well plates. The bottom of the devices are formed by #1.5 (180µm) cover slip glass optimized for high resolution microscopy data.



 



 

BioFlux System Configurations

BioFlux 200 Core control system, integrates to any inverted microscope

BioFlux 1000 Fully integrated
solution with automated microscopy


Key Features

Adds biological relevance of shear flow

Simplifies complex functional assays

Reduces experimental project time from months to days

Increases reliability and reproducibility of flow assays

Easily integrates with any inverted microscope

Fully integrated version available with automated microscopy

Representative Applications

Vascular biology - platelet adhesion, thrombosis, endothelial cells

Oncology - cellular adhesion,
transmigration, chemotaxis

Immunology - migration, invasion, leukocyte adhesion

Microbiology - biofilm growth, anti-microbial screening

Drug discovery - compound profiling, library screening

   
     
©2011 Fluxion Biosciences, Inc,   |   info@fluxionbio.com   |    (866) 266-8380 Toll Free   |   Privacy Policy