Pharmacological Characterization of a Primary Nicotinic Receptor from the Neuromuscular Junction
Thursday May 26th. 11am Eastern, 12pm Central, 10am Pacific
Speakers: Andrew Cook,...
At Fluxion, we’re passionate about delivering cell-based and cell-free solutions that facilitate the transformation of research discoveries into new ways to diagnose and treat patients. By characterizing molecular and cellular mechanisms of disease, Fluxion’s platforms help bridge the translational medicine gap, enabling rapid advances in disease research, drug discovery, and the development of diagnostic tests.
IonFlux from Fluxion Biosciences has been designed to circumvent any drug delivery limitation found in complicated ion channel assays while still performing Giga-ohm seal high quality recordings. With unique benefits such as in-plate liquid exchange, continuous solution flow and physiological temperature control, high throughput ion channel recordings are possible without any sacrifice in performance and data quality.
Due to its unique liquid exchange system, IonFlux is the ideal platform for ligand binding, allosteric modulation, multiple agonists, and voltage- and temperature-sensitive assays. It is used in laboratories and research centers worldwide for various voltage gated and ligand gated ion channels assays.
From safety pharmacology to sleep disorders, ion channel research and screening assays are simplified with IonFlux technology. Read more about ion channel applications with IonFlux.
IonFlux provides the highest degree of control over fluidics for specialized ion channel assays. With its unique microfluidic plates, IonFlux is the only system where all cell recordings and liquid exchange are performed within the plate proper. Without the hindrance of liquid handlers, the system advances high throughput ion channel experiments by providing unique attributes that permit specialized assays, impossible or impractical using other asynchronous systems.
IonFlux from Fluxion Biosciences comes in different versions catering to different laboratories and project needs. download the product brochures and the selection guide to research the best system for your needs.
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IonFlux Mercury 16 represents the next generation in the automated patch clamp system. With features such as 16 parallel recordings using 16 independent amplifiers, remote and touch screen experiment execution, highly extended recording times, exceptionally fast fluid exchange system, standardized temperature control, and optional current clamp. IonFlux Mercury is the most compact yet full featured stand-alone high throughput automated patch clamp instrument on the market.
The IonFlux Mercury HT takes all the technology of the IonFlux Mercury 16 and multiplies the throughput by 4. With 64 amplifiers, continuous flow and extremely flexible liquid exchange, the IonFlux Mercury HT can sometimes be the only means to achieve higher throughput with extremely complicated flow-dependent ion channel assays.
IonFlux Mercury Ultra is the latest iteration of the industry-leading IonFlux platform, with enhancements in every aspect of the technology. With 256 independent amplifiers capable of non-stop recordings, and an uninterrupted sweep length of up to 300 seconds, IonFlux Mercury Ultra extends the IonFlux system’s industry-leading capabilities in compound delivery, rapid solution exchange, and assay flexibility. Now, the most complicated ligand-gated and demanding voltage-gated assays can run in parallel, decreasing experiment time and accelerating completion of projects.
Medium Throughput
data points / hour
16 Amplifier channels
Single cell GigaOhm seal / 20 cell ensemble
Continuous solution flow
Uses SBS standard 96 well plates
in-plate liquid handling
144 data point / plate
Synchronous Assays
8 independent experiments
Up to 16 different intracellular solution per assay
Integrated temperature control ambient to 40 degrees Celsius
High Throughput
data points / hour
64 Amplifier channels
Single cell GigaOhm seal / 20 cell ensemble
Continuous solution flow
Uses SBS standard 384 well plates
in-plate liquid handling
576 data point / plate
Synchronous Assays
32 independent experiments
Up to 64 different intracellular solution per assay
Integrated temperature control ambient to 40 degrees Celsius
Ultra High Throughput
data points / hour
128/256 Amplifier channels
Single cell GigaOhm seal / 20 cell ensemble
Continuous solution flow
Uses SBS standard 384 well plates
in-plate liquid handling
2304 data point / plate
Synchronous / Asynchronous Assays
128 independent experiments
Up to 256 different intracellular solution per assay
Integrated temperature control ambient to 40 degrees Celsius
IonFlux utilizes in-plate solution transfer that is made possible by SBS standard plates with intricate microfluidics
Visit our library of application notes, webinars, live demos, posters and publications featuring BioFlux technology.
For additional support, customers can access our support site for operation technical guides, cell culture optimizations, software updates, pre-recorded training, and troubleshooting guides.
Thursday May 26th. 11am Eastern, 12pm Central, 10am Pacific
Speakers: Andrew Cook,...
Speaker: Dr. Andrew Jenkins Ph.D, Associate Professor, Faculty of Pharmacy &...
Speaker: Dr. Khaled Barakat PhD, Assistant Professor, Faculty of Pharmacy &...