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At Fluxion, we’re passionate about delivering cell-based and cell-free solutions that facilitate the transformation of research discoveries into new ways to diagnose and treat patients. By characterizing molecular and cellular mechanisms of disease, Fluxion’s platforms help bridge the translational medicine gap, enabling rapid advances in disease research, drug discovery, and the development of diagnostic tests.

Automated Patch Clamp

IonFlux Mercury
Systems

Industry Leading Flexibility and Performance in High Throughput Patch Clamp Assays

IonFlux from Fluxion Biosciences has been designed to circumvent any drug delivery limitation found in complicated ion channel assays while still performing Giga-ohm seal high quality recordings. With unique benefits such as in-plate liquid exchange, continuous solution flow and physiological temperature control, high throughput ion channel recordings are possible without any sacrifice in performance and data quality.

IonFlux Application Areas

Due to its unique liquid exchange system, IonFlux is the ideal platform for ligand binding, allosteric modulation, multiple agonists, and voltage- and temperature-sensitive assays. It is used in laboratories and research centers worldwide for various voltage gated and ligand gated ion channels assays.

IonFlux Application Areas

From safety pharmacology to sleep disorders, ion channel research and screening assays are simplified with IonFlux technology. Read more about ion channel applications with IonFlux.

Ion Channel Applications

IonFlux Technology

IonFlux provides the highest degree of control over fluidics for specialized ion channel assays. With its unique microfluidic plates, IonFlux is the only system where all cell recordings and liquid exchange are performed within the plate proper. Without the hindrance of liquid handlers, the system advances high throughput ion channel experiments by providing unique attributes that permit specialized assays, impossible or impractical using other asynchronous systems.

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How to Choose the best IonFlux for your Needs

IonFlux from Fluxion Biosciences comes in different versions catering to different laboratories and project needs. download the product brochures and the selection guide to research the best system for your needs.

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IonFlux Mercury Brochure

IonFlux System Selection Guide

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IonFlux System Selection Guide

IonFlux Mercury 16

PATCH CLAMP AUTOMATION AT THE PRICE OF MANUAL

IonFlux Mercury 16 represents the next generation in the automated patch clamp system. With features such as 16 parallel recordings using 16 independent amplifiers, remote and touch screen experiment execution, highly extended recording times, exceptionally fast fluid exchange system, standardized temperature control, and optional current clamp. IonFlux Mercury is the most compact yet full featured stand-alone high throughput automated patch clamp instrument on the market.

Mercury 16

IonFlux Mercury HT

HIGH THROUGHPUT AUTOMATION FOR FLOW DEPENDENT ASSAYS

The IonFlux Mercury HT takes all the technology of the IonFlux Mercury 16 and multiplies the throughput by 4. With 64 amplifiers, continuous flow and extremely flexible liquid exchange, the IonFlux Mercury HT can sometimes be the only means to achieve higher throughput with extremely complicated flow-dependent ion channel assays.

Mercury HT

IonFlux Mercury ULTRA

THE HIGHEST THROUGHPUT CONTINUOUS FLOW APC SYSTEM ON THE MARKET 

IonFlux Mercury Ultra is the latest iteration of the industry-leading IonFlux platform, with enhancements in every aspect of the technology. With 256 independent amplifiers capable of non-stop recordings, and an uninterrupted sweep length of up to 300 seconds, IonFlux Mercury Ultra extends the IonFlux system’s industry-leading capabilities in compound delivery, rapid solution exchange, and assay flexibility. Now, the most complicated ligand-gated and demanding voltage-gated assays can run in parallel, decreasing experiment time and accelerating completion of projects.

Full Machine-1

IonFlux Mercury 16

Medium Throughput

700

data points / hour

16 Amplifier channels

Single cell GigaOhm seal / 20 cell ensemble

Continuous solution flow

Uses SBS standard 96 well plates

in-plate liquid handling

144 data point / plate

Synchronous Assays

8 independent experiments

Up to 16 different intracellular solution per assay

Integrated temperature control ambient to 40 degrees Celsius

IonFlux Mercury HT

High Throughput

2500

data points / hour

64 Amplifier channels

Single cell GigaOhm seal / 20 cell ensemble

Continuous solution flow

Uses SBS standard 384 well plates

in-plate liquid handling

576 data point / plate

Synchronous Assays

32 independent experiments

Up to 64 different intracellular solution per assay

Integrated temperature control ambient to 40 degrees Celsius

IonFlux Mercury Ultra

Ultra High Throughput

10000

data points / hour

128/256 Amplifier channels

Single cell GigaOhm seal / 20 cell ensemble

Continuous solution flow

Uses SBS standard 384 well plates

in-plate liquid handling

2304 data point / plate

Synchronous / Asynchronous Assays

128 independent experiments

Up to 256 different intracellular solution per assay

Integrated temperature control ambient to 40 degrees Celsius

Its all in the consumables

IonFlux utilizes in-plate solution transfer that is made possible by SBS standard plates with intricate microfluidics

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IonFlux Plate - 96 well Photo-1

Automate IonFlux Assays

Mercury Automate is a new Liquid Handler specially configured for IonFlux assays. Included free with IonFlux Mercury HT and ULTRA

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automate

Resources Library & Support Center

Visit our library of application notes, webinars, live demos, posters and publications featuring IonFlux technology.

Resources Library

 

For additional support, customers can access our support site for operation technical guides, cell culture optimizations, software updates, pre-recorded training, and troubleshooting guides.

Support Center

 

 

Latest Webinars

Pharmacological Characterization of a Primary Nicotinic Receptor from the Neuromuscular Junction

Speakers: Andrew Cook, Senior Study Director, Eurofins Discovery Services

Abstract:

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GABA(A) Receptors and Disease

Speaker: Dr. Andrew Jenkins Ph.D, Associate Professor, Faculty of Pharmacy &...

A Novel Way to Study hERG Drug Liability

Speaker: Dr. Khaled Barakat PhD, Assistant Professor, Faculty of Pharmacy &...

Latest Application Notes

Latest Publications

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Contact us for more information about IonFlux systems. 

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